Fatal Case of Dichloromethane Poisoning
Identifieur interne : 001A30 ( Main/Exploration ); précédent : 001A29; suivant : 001A31Fatal Case of Dichloromethane Poisoning
Auteurs : Jean-Pierre Goullé [France] ; Christian Lacroix [France] ; Emmanuelle Vaz [France] ; Philippe Rouvier [France] ; Bernard Proust [France]Source :
- Journal of Analytical Toxicology [ 0146-4760 ] ; 1999-09.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Methylene Chloride.
- chemical , metabolism : Methylene Chloride.
- chemical , poisoning : Methylene Chloride.
- Fatal Outcome, Gas Chromatography-Mass Spectrometry, Humans, Male, Middle Aged, Tissue Distribution.
Abstract
A 47-year-old man was found dead in a factory where dichloromethane (DCM) tanks were stocked. He was making an inventory of the annual stock of DCM contained in several tanks (5- to 8000-L capacity) by transferring the solvent into an additional tank with the help of compressed air. During this operation, one of the tanks overflowed and the man, who was not wearing any protection, was intoxicated. Autopsy showed digestive, suprarenal, and liver bleeding. Blood was also found in the trachea. DCM was identified by headspace gas chromatography-mass spectrometry (GC-MS). A headspace gas chromatography-flame ionization detection technique (GC-HS-FID) optimized for quantitation in biological fluids, organs and viscera was established at autopsy. The following concentrations of DCM were found: blood (150 mg/L), urine (2.0 mg/L), gastric content (5.6 mg/L), brain (122 mg/kg), fat (99 mg/kg), liver (44 mg/kg), lung (20 mg/kg), and kidney (15 mg/kg). A study of the storage stability of DCM was carried out on these samples. Ethanol production was measured in some organs. The results are discussed in light of the rarity of existing literature.
Url:
DOI: 10.1093/jat/23.5.380
Affiliations:
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sortKey="Rouvier, Philippe" sort="Rouvier, Philippe" uniqKey="Rouvier P" first="Philippe" last="Rouvier">Philippe Rouvier</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Institut de Médecine Légale, Centre Hospitalier Régional et Universitaire, 1 rue de Germont, 76031 Rouen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Proust, Bernard" sort="Proust, Bernard" uniqKey="Proust B" first="Bernard" last="Proust">Bernard Proust</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Institut de Médecine Légale, Centre Hospitalier Régional et Universitaire, 1 rue de Germont, 76031 Rouen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Analytical Toxicology</title><title level="j" type="abbrev">Journal of Analytical Toxicology</title><idno type="ISSN">0146-4760</idno><idno type="eISSN">1945-2403</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1999-09">1999-09</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="380">380</biblScope><biblScope unit="page" to="383">383</biblScope></imprint><idno type="ISSN">0146-4760</idno></series><idno type="istex">55CF7DBD4DFBBCD0A8650257152BA57EB80E2D3A</idno><idno type="DOI">10.1093/jat/23.5.380</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-4760</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Fatal Outcome</term><term>Gas Chromatography-Mass Spectrometry</term><term>Humans</term><term>Male</term><term>Methylene Chloride (analysis)</term><term>Methylene Chloride (metabolism)</term><term>Methylene Chloride (poisoning)</term><term>Middle Aged</term><term>Tissue Distribution</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Methylene Chloride</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Methylene Chloride</term></keywords><keywords scheme="MESH" type="chemical" qualifier="poisoning" xml:lang="en"><term>Methylene Chloride</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Fatal Outcome</term><term>Gas Chromatography-Mass Spectrometry</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Tissue Distribution</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">A 47-year-old man was found dead in a factory where dichloromethane (DCM) tanks were stocked. He was making an inventory of the annual stock of DCM contained in several tanks (5- to 8000-L capacity) by transferring the solvent into an additional tank with the help of compressed air. During this operation, one of the tanks overflowed and the man, who was not wearing any protection, was intoxicated. Autopsy showed digestive, suprarenal, and liver bleeding. Blood was also found in the trachea. DCM was identified by headspace gas chromatography-mass spectrometry (GC-MS). A headspace gas chromatography-flame ionization detection technique (GC-HS-FID) optimized for quantitation in biological fluids, organs and viscera was established at autopsy. The following concentrations of DCM were found: blood (150 mg/L), urine (2.0 mg/L), gastric content (5.6 mg/L), brain (122 mg/kg), fat (99 mg/kg), liver (44 mg/kg), lung (20 mg/kg), and kidney (15 mg/kg). A study of the storage stability of DCM was carried out on these samples. Ethanol production was measured in some organs. The results are discussed in light of the rarity of existing literature.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Le Havre</li><li>Rouen</li></settlement></list><tree><country name="France"><region name="Région Normandie"><name sortKey="Goulle, Jean Pierre" sort="Goulle, Jean Pierre" uniqKey="Goulle J" first="Jean-Pierre" last="Goullé">Jean-Pierre Goullé</name></region><name sortKey="Lacroix, Christian" sort="Lacroix, Christian" uniqKey="Lacroix C" first="Christian" last="Lacroix">Christian Lacroix</name><name sortKey="Proust, Bernard" sort="Proust, Bernard" uniqKey="Proust B" first="Bernard" last="Proust">Bernard Proust</name><name sortKey="Rouvier, Philippe" sort="Rouvier, Philippe" uniqKey="Rouvier P" first="Philippe" last="Rouvier">Philippe Rouvier</name><name sortKey="Vaz, Emmanuelle" sort="Vaz, Emmanuelle" uniqKey="Vaz E" first="Emmanuelle" last="Vaz">Emmanuelle Vaz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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